Perry J, Haughton V, Anderson PA, Wu Y, Fine J, Mistretta C. The value of T2 relaxation times to characterize lumbar intervertebral disks: preliminary results. Jaeschke R, Singer J, Guyatt GH. Spine J. Bogduk N, Karasek M. Two-year follow-up of a controlled trial of intradiscal electrothermal anuloplasty for chronic low back pain resulting from internal disc disruption. 2004 Nov-Dec;4(6 Suppl):190S-194S. These fingerprints are compared with a dictionary of simulated fingerprints generated for that sequence by a pattern matching process.
J Tissue Eng Regen Med. The paper, “Cell therapy for intervertebral disc herniation and degenerative disc.

1998 Dec;80(12):1745-57. MSCs will be isolated and cultured in the Case Western Reserve University National Center for Regenerative Medicine/Seidman Cancer Center Cellular Therapy Lab using standard operating procedures established under the ongoing IND - as above. Have a positive screen for human immunodeficiency virus (HIV) by antibodies or nucleic acid test. Spine (Phila Pa 1976). 2005 Jan;34(1):8-12. Review. Rev Saude Publica 49:1518–.

Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Routine images of the lumbar spine (sagittal and axial T1 and T2 weighted images) will be obtained for the purposes of: Monitoring for potential alternative effects of the cells including osteophyte formation, as well as any unexpected local outcome. The MAVERICK™ Artificial Disc could potentially offer another option to these patients that may better restore function of the lumbar spine. The purpose of this study is to expand biobanking to neurosurgical disorders where similar protocols do not exist in the institution (e.g., neurovascular disease) and complement existing biobanking protocols where they do exist (e.g., neuro-oncology, skull base tumors, degenerative spine). Pain. It eliminates the need for fusing the vertebrae together. Murphy CL, Thoms BL, Vaghjiani RJ, Lafont JE. Meisel HJ, Siodla V, Ganey T, Minkus Y, Hutton WC, Alasevic OJ. Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. An overview of the incidences and costs of low back pain. Concurrent participation in another investigational trial involving systemic administration of agents or within the previous 30 days. J Am Acad Orthop Surg. Virgin IslandsU.S. Maughan EF, Lewis JS. 2004 Jul 15;29(14):1508-14. In the event of a positive microbial test following administration of a cellular product: 1) The Principal Investigator and his/her designee will be notified and will notify the participant, 2) The contaminant will identified to a species level and antibiotic sensitivities determined, 3) The Medical Director of the Cellular Therapy Laboratory and/or the Principal Investigator will determine the best course of action based on the clinical situation.

When stem cells are injected in to the degenerated disc, the cells help stimulate the disc to repair itself.

These surgeries usually entail a fusion often with the use of instrumentation such as rods, screws, and cages. how the patient responded to medications and non-surgical treatments for their symptoms. Degenerative Lumbar Spine Disease: Estimating Global Incidence and Worldwide Volume. Biol Blood Marrow Transplant. Patients reported significant improvement in pain and disability scores. Shuff C, An HS. Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation. The exterior of a disc (the annulus fibrosus) is tough and made up of layers of collagen fibres. History or laboratory results indicative of any significant cardiac, endocrine, hematologic, hepatic, immunologic, infectious, metabolic, urologic, pulmonary, gastrointestinal, dermatologic, psychiatric, renal, neoplastic, or other disorder that in the opinion of the Principal Investigator or his/her designee would preclude the safe performance of BM aspiration, transplantation of autologous MSCs, or performance of any of the planned study assessments. 2002 Aug 1;27(15):1626-33. Spine J. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. ... degenerative disk disease. 2005 May;11(5):389-98. into the epidural space surrounding the spinal cord) for short-term pain relief; Cognitive behavioural therapy (CBT) is recommended in some patients. Monfort J, Garcia-Giralt N, López-Armada MJ, Monllau JC, Bonilla A, Benito P, Blanco FJ. Spine centers and pain clinics across the U.S. are currently accepting participants in a clinical research study of a new non-surgical study treatment for degenerative disc disease (DDD). Epub 2010 Apr 17. 1990 May;15(5):411-5.