Moreover, the significant contribution of EGFR and ERβ in the morphological characteristics of these cells is also demonstrated, hence highlighting the possibility of dual pharmacological targeting. We further show that free fatty acid (FFA) or lipopolysaccharide are both able to trigger release of TNF from Kupffer cells. These results suggest that the mechanism of KDM2A activation by gallic acid may be applicable to the treatment of breast cancers. Moreover, these cells are more viable when treated with rotenone, an agent that mimics PD pathology.

Images obtained by scanning electron microscope (SEM) from cultures on the different matrix substrates revealed novel observations regarding various structures of breast cancer cells (filopodia, extravesicles, tunneling nanotubes, etc.). However, in co-cultures or supernatant transfer experiments, we show that tumor necrosis factor (TNF) secretion by Kupffer cells is necessary and sufficient to induce steatosis in hepatocytes, independent of the challenge of hepatocytes with elevated fatty acid levels. Increase your article citation. Gallic acid did not induce KDM2A-dependent anti-proliferation activity in non-tumorigenic MCF10A cells. (This article belongs to the Special Issue, Metformin, which is suggested to have anti-cancer effects, activates KDM2A to reduce rRNA transcription and proliferation of cancer cells.

A method for measuring intra-tissue swelling pressure using a needle micro-osmometer, HC Lin, CK Wang, YC Tung, FY Chiu, YP Su eCM highlights published papers through social media platforms. At Cell Press, we understand that the impact factor is just one measure of journal performance. These results suggest that both ROS production and AMPK activation are required for activation of KDM2A by gallic acid. Submission deadline: 30th of September 2020, Dental Regenerative Biology Special Issue: This Special Issue intends to provide a comprehensive overview of how dental tissues respond to destructive insults, highlight the cues that are involved in their regeneration and report on the most recent developments in dental regeneration involving a combination of tissue engineering and stem-cell biology. those of the individual authors and contributors and not of the publisher and the editor(s). Spanish Society for Biochemistry and Molecular Biology (SEBBM), Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy, Revisiting the Karyotype Evolution of Neotropical Boid Snakes: A Puzzle Mediated by Chromosomal Fissions, Learning from Fifteen Years of Genome-Wide Association Studies in Age-Related Macular Degeneration, Molecular and Cellular Basis of Macular Degenerations, Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription, Ribosome Biogenesis in Health and Disease, The Multimodal Serotonergic Agent Vilazodone Inhibits L-DOPA-Induced Gene Regulation in Striatal Projection Neurons and Associated Dyskinesia in an Animal Model of Parkinson’s Disease, Molecular and Cellular Mechanisms of Parkinson's Disease, Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells, Molecular and Neurobiological Basis of Pain Sensation Involved in Fibromyalgia and Peripheral Neuropathy, The Functional Role of microRNAs in the Pathogenesis of Tauopathy, Non-Coding RNAs and Neurological Diseases, Astrogliosis in an Experimental Model of Hypovitaminosis B12: A Cellular Basis of Neurological Disorders due to Cobalamin Deficiency, Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration, Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation, Regulation of Lipid Metabolism in Health and Disease, Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD), ΕGFR/ERβ-Mediated Cell Morphology and Invasion Capacity Are Associated with Matrix Culture Substrates in Breast Cancer, The Multifaceted Nature of Epithelial to Mesenchymal Transition (EMT): From Embryonic Development to Cellular Plasticity in Normal Tissue and Tumors, HSP90 Co-Chaperone, CacyBP/SIP, Protects α-Synuclein from Aggregation, Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility, Premature Vascular Aging with Features of Plaque Vulnerability in an Atheroprone Mouse Model of Hutchinson–Gilford Progeria Syndrome with, The New Frontier of Therapies for Nuclear Envelope and Lamin-Related Diseases: Selected Papers from 2019 International Meeting on Laminopathies, The Primary Cilium of Adipose Progenitors Is Necessary for Their Differentiation into Cancer-Associated Fibroblasts that Promote Migration of Breast Cancer Cells In Vitro, Safety and Tolerability of Stromal Vascular Fraction Combined with β-Tricalcium Phosphate in Posterior Lumbar Interbody Fusion: Phase I Clinical Trial, Discounts/Waivers Application for Your Submission, Biomolecules Webinar | Recent advances on lysosomal storage disorders pathogenesis: an emerging Gaucher disease paradigm shift, Cell-to-Cell Metabolic Cross-Talk in Physiology and Pathology, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases, Leukocytes in Inflammation, Resolution of Inflammation, Autoimmune Diseases and Cancer, Mechanobiology Defects in Muscular Disorders, Sphingolipids in Cancer Progression and Therapy, Regulation of Erythropoiesis—Building a Red Blood Cell, Membrane Lipids in the Interaction of Plants with Their Abiotic and Biotic Environment, Feature Papers in Cell Motility and Adhesion.
The Effect of Aerobic Training and Tribulus terrestris Extract on Some Oxidative Stress Indices in the Heart Tissue of Male Wistar Rats Poisoned with Hydrogen Peroxide Hepatocytes react by alteration in lipid metabolism prominently leading to the accumulation of triacylglycerols (TAGs) in lipid droplets, a hallmark of steatosis. Recently, it has been found that the CacyBP/SIP protein acts as HSP90 co-chaperone and exhibits chaperone properties itself. Specifically, we show that highly metastatic or chemotherapy-treated breast cancer cells shed an increased number of TMPs compared to their respective controls. Thus, the specific activation of KDM2A may be applicable to the treatment of cancers. Our results demonstrate that these pro-metastatic effects are mediated in part by CD44 which is highly expressed in TMPs obtained from highly metastatic cells or cells exposed to chemotherapy when compared to cells with low metastatic potential. Specifically, abnormal EGFR activation leads to altered matrix metalloproteinases’ (MMPs) expression and, hence, extracellular matrix (ECM) degradation, resulting in induced migration and invasion. These data have important implications for the interpretation of studies observing tissue-protective effects of this dynamin inhibitor as well as raise awareness that off-target ROS scavenging activities of small molecules used to interrogate the ferroptosis pathway should be taken into consideration. We found that these TMPs substantially reduce cell adhesion and disrupt actin filament structure, therefore increasing their biomechanical force pace, further implicating tumor cell dissemination as part of the metastatic cascade.

0.907 Animal Cells and Systems. Submission deadline: 1st of November 2020, Orthopaedic Infection Special Issue: Orthopaedic infections, including fracture-related infection (FRI), peri-prosthetic joint infection (PJI), septic arthritis and osteomyelitis, remain amongst the most challenging complications in orthopaedic and musculoskeletal surgery.