Periodic blood work to monitor your complete blood count (CBC) will be ordered by your doctor. Of the identified cases, 69 cancer patients were evaluable. Among the patients who received pegfilgrastim for primary prophylaxis, 8% were hospitalized for febrile neutropenia. Gentle exercise is encouraged such as a daily walk. The treatment puts your bone morrow on overdrive in an effort to build up your white cells before the next chemo session gets to destroy them again. If you experience symptoms or side effects, be sure ot discuss them with your health care team. The number of days you receive filgrastim will be prescribed by your doctor. You should receive filgrastim either before or after the chemotherapy, depending on your blood count results and your doctor's directions. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Efficacy of Plinabulin vs Pegfilgrastim for Prevention of Chemotherapy-Induced Neutropenia in Adults With Non-Small Cell Lung Cancer: A Phase 2 Randomized Clinical Trial.  |  Do not receive any kind of immunization or vaccination without your doctor's approval while taking filgrastim. You may report side effects to the FDA at 1-800-FDA-1088.

You should discuss this with your doctor. Pregnancy category C (use the pregnancy only when benefit to the mother outweighs risk to the fetus). Predicting neutropenia risk in patients with cancer using electronic data. 2015 Feb;23(2):525-45. doi: 10.1007/s00520-014-2457-z.

J Am Med Inform Assoc. Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: a retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF). Most people will not experience all of the filgrastim side effects listed. Bone pain … COVID-19 is an emerging, rapidly evolving situation. Sucking on lozenges, and chewing gum may also help. Upsides Neulasta (pegfilgrastim) is … Bone pain. 2017 Apr 1;24(e1):e129-e135. Filgrastim is generally given on a daily basis. 2015 Nov;23(11):3131-40. doi: 10.1007/s00520-015-2686-9. Commonly reported side effects of filgrastim include: hyperuricemia, increased lactate dehydrogenase, increased leukocyte alkaline phosphatase, increased serum alkaline phosphatase, ostealgia, and thrombocytopenia.Other side effects include: arthralgia, headache, myalgia, and pruritus. These side effects are less common side effects (occurring in about 10-29%) of patients receiving filgrastim: Safety and Efficacy of Pegfilgrastim When Given Less Than 14 Days Before the Next Chemotherapy Cycle: Review of Every 14-Day Chemotherapy Regimen Containing 5-FU Continuous Infusion. Blayney DW, Zhang Q, Feng J, Zhao Y, Bondarenko I, Vynnychenko I, Kovalenko N, Nair S, Ibrahim E, Udovista DP, Mohanlal R, Ogenstad S, Ette E, Du L, Huang L, Shi YK. For information about the 4th Angel Mentoring Program visit www.4thangel.org, Call the Cancer Answer Line at Cleveland Clinic. 2017 Oct;51(10):840-847. doi: 10.1177/1060028017714554. This content does not have an Arabic version. Loratadine targets histamine, and so may be effective in reducing bone pain.The researchers plan to prospectively assess the effectiveness of loratadine for chronic bone pain in patients with chronic G-CSF use. The rates of bone pain vary between agents, and may be associated with higher doses such as those used for stem cell mobilization (eg, filgrastim 10 mcg/kg). It is given either by injection into a vein or under the skin. Important things to remember about the side effects of filgrastim. Filgrastim should be refrigerated. For women: Do not conceive a child (get pregnant) while taking filgrastim. The amount of filgrastim that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Please enable it to take advantage of the complete set of features! The most commonly reported side effects included bone pain, skeletal pain, medullary bone pain, and spontaneously reversible mild to moderate lactate dehydrogenase elevations. In patients receiving chemotherapy, filgrastim can accelerate the recovery of neutrophils, reducing the neutropenic phase (the time in which people are susceptible to infections). Purpose: Bone pain is a common adverse effect of the granulocyte colony-stimulating factors filgrastim and pegfilgrastim. Bone pain is a common adverse effect of the granulocyte colony-stimulating factors filgrastim and pegfilgrastim. Along with its needed effects, a medicine may cause some unwanted effects. Pegfilgrastim is commonly used for primary prophylaxis during the first cycle of chemotherapy. However, the incidence of reported bone pain varies and therapies to mitigate this adverse effect are limited to case reports and one randomized controlled trial. Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. Remove from refrigerator 30 minutes before injection.  |  If you notice any other effects, check with your healthcare professional. Purpose: Filgrastim may be given subcutaneous (the layer between the skin and muscle) injection or infused into a vein (intravenous, IV). Conclusions: The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice. Petechiae (a small red or purple bump, which is caused by bleeding under the skin), Fever of 100.4° F (38° C) or higher, chills (possible signs of infection), Bleeding that does not stop after a few minutes, Bone pain that does not go away despite taking recommended pain reliever. The impact of primary prophylaxis with granulocyte colony-stimulating factors on febrile neutropenia during chemotherapy: a systematic review and meta-analysis of randomized controlled trials.

2019 Oct;11(4):371-375. doi: 10.3892/mco.2019.1907. Copyright © 2020 IBM Watson Health. doi: 10.1093/jamia/ocw131. You may experience bone or joint pain as a result of this medication. There are many options to minimize or prevent the side effects of filgrastim.