Structural and mutagenic analysis of relaxed nucleotide specificity.
The cell wall complex contains peptidoglycan , but otherwise it is composed of complex lipids. Mycobacterium tuberculosis (M. tb) is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis.

This coating makes the cells impervious to Gram staining, and as a result, M. tuberculosis can appear either Gram-negative or Gram-positive. Acid-fast stains such as Ziehl-Neelsen, or fluorescent stains such as auraminea…

Much of the early structural definition of the cell wall of Mycobacterium spp. The cell wall structure of Mycobacterium tuberculosis deserves special attention because it is unique among procaryotes, and it is a major determinant of virulence for the bacterium.

was initiated in the 1960s and 1970s. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8 million annually.Mtb RNA polymerase (RNAP) is the target of the first-line antituberculosis drug rifampin (Rif).


First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. We report crystal structures of Mtb RNAP, alone and in complex with Rif, at 3.8–4.4 Å resolution. Domain: Bacteria; Phylum: Actinobacteria;Class: Actinobacteria;Order: Actinomycetales;family: Mycobacteriaceae;Genus: Mycobacterium