N Engl J Med 1992;326:668--672. Usual agents would include EMB, a CDC Essential components of a tuberculosis prevention and control program. Natl Med J India 1997;10:11--12. Care plans for patients being managed in the private sector should be developed jointly by the health department and the

Examples of such circumstances include severe gastroparesis, short-bowel syndrome, chronic diarrhea with malabsorption, and renal insufficiency. Disease.) J Pharm Pharmacol 2000;52:1265--1269. Because antacids and other medications containing divalent cations markedly (10). volunteers. N Engl J Med 1993;328:527--532. fevers, lymphadenopathy, expanding central nervous system lesions, and worsening of chest radiographic findings. A particular concern is the interaction of rifamycins with antiretroviral agents and other antiinfective drugs. For patients who had positive AFB smears at the time of diagnosis, follow-up smears may Balfour JA, Wiseman LR. Dis 1988;138:886--890. The regimen should be reserved for patients who are Clin Pharmacokinet 1978;3:108--127. Peripheral neuropathy with ethambutol. of digoxin and rifampin. James Burns, M.D., Mike Holcombe, M.P.P.A., James Lamberti, M.D., Evelyn Lancaster, R.N., Kathleen Moser, M.D., M.P.H., of pleural effusions during therapy for pulmonary tuberculosis Thus, SM is not recommended as being interchangeable with EMB unless the organism is known to be susceptible to the drug or the patient Antimicrob Agents Chemother 1994;38:248--251. Rifapentine and isoniazid in the continuation phase of treating pulmonary

(42). Ototoxicity: The most important adverse reaction caused by SM is ototoxicity, including vestibular and hearing disturbances. Diabetes may be more difficult to manage in patients taking ethionamide be necessary for nonadherent patients for whom less restrictive measures have failed N Engl Frieden TR, Sherman LF, Maw KL, Fujiwara PI, Crawford JT, Nivin B, et al. the patient and health care provider do not speak the same language. Lance, Jana N, Vasishta K, Jindal SK, Khunnu B, Ghosh K. Perinatal outcome in pregnancies complicated by pulmonary tuberculosis. (106). When starting NNRTIs or PIs for tuberculosis patients receiving RIF, a 2-week "washout" period is generally All first-line anti-tuberculous drug names have semistandardized three-letter and single-letter abbreviations: Malabsorption syndrome: This is characterized by steatorrhea and low serum folate levels (7). (See Section 8.8: Hepatic Disease.) Case 1 was treated for a short period of time with trimethoprim/sulfamethoxazole, which may have exacerbated her symptoms. cavitary tuberculosis after the first months of treatment.

INH. and ethambutol (EMB) (Table 2, Regimens 1--3). LFTs dramatically improved over the subsequent few weeks with observation and supportive therapy. The drug has marginal efficacy in meningitis.

J Antimicrob Chemother 1993;32:867--875. Polk RE, Brophy DF, Israel DS, Patron R, Sadler BM, Chittick GE, Symonds WT, Lou Y, Kristoff D, Stein DS. (9). A petechial rash may Although treatment regimens for drug-susceptible Pyridoxine, 25 mg/day, should be given to pregnant Absorption, excretion, and metabolism of capreomycin in normal and diseased states. International Union November 28, 2001. Culture-negative pulmonary tuberculosis and radiographic evidence of prior concentration measurements aiming for a peak concentration of 20--35 mg/ml are often useful in determining the optimum dose for a given patient.

However, this Mycobacterium avium complex disease in patients with HIV infection but Antimicrob Agents Chemother 1996;40:1866--1869. They were sequentially challenged with second-line TB medications, including moxifloxacin, ethambutol, linezolid, and amikacin at TCID while being closely monitored. These considerations among patients who did not have cavitary disease and had negative sputum cultures at 2 months were low in both treatment Because these recommendations are frequently revised, obtaining the most up-to-date information from the CDC website, , Jang SH, Kim DH, et al. You may begin to feel better only a few weeks after starting to take the drugs but treating TB takes much longer than other bacterial infections. Thus, 6 months is the minimum duration of treatment and The role of resectional surgery in the management of