Stem cell therapy, such as potential use of human mesenchymal stem cells and induced pluripotent stem cells and their exosomes, will make it possible not only to address molecular mechanisms of cardiac conditioning, but also to develop new therapies for ischemic heart disease. They do this by secreting local hormones to rescue damaged heart cells and occasionally turning into heart muscle cells themselves. By continuing you agree to the use of cookies. Nevertheless, there has been considerable attention to safety by the clinical investigators because the adverse events of stem cell therapy have been impressively rare.

Different types of stem cells have been used for stem cell therapy. Despite considerable advances in medicine, cardiovascular disease is still rising, with ischemic heart disease being the leading cause of death and disability worldwide.
This work was supported in part by grants P01GM066730 and T32 GM089586 from the National Institutes of Health, Bethesda, MD. Clinical trials using primary bone-marrow-derived cells and skeletal myoblasts have also shown some encouraging results. Thus extensive efforts are continuing to establish effective therapeutic modalities that would improve both quality of life and survival in this patient population. Despite the studies and progress made over the last 15 years on the use of stem cell therapy for cardiovascular disease, the efforts are still in their infancy. Because of many negative findings, there is certain pessimism that cardiac cell therapy … Journal of Cardiothoracic and Vascular Anesthesia, https://doi.org/10.1053/j.jvca.2018.04.048. Even though the expectations have been high, the findings indicate that most of the clinical trials generally have been small and the results inconclusive. Because of many negative findings, there is certain pessimism that cardiac cell therapy is likely to yield any meaningful results over the next decade or so. Copyright © 2020 Elsevier B.V. or its licensors or contributors. The partially repaired tissue … But they could do better – for some reason, the heart stops signaling for heart cells after only a week or so after the damage has occurred, leaving the repair job mostly undone.

© 2018 Elsevier Inc. All rights reserved. In summary, although regenerative biology might not help the cardiovascular patient in the near term, it is destined to do so over the next several decades. Stem Cell Therapies in Cardiovascular Disease. Similar to other new technologies, early failures are not unusual and they may be followed by impressive success. We use cookies to help provide and enhance our service and tailor content and ads. Stem cells do a fairly good job. Novel therapies are being investigated not only to protect the myocardium against ischemia-reperfusion injury but also to regenerate the heart. There, they may help heal damaged tissue. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Even though the expectations have been high, the findings indicate that most of the clinical trials generally have been small and the results inconclusive. Despite the studies and progress made over the last 15 years on the use of stem cell therapy for cardiovascular disease, the efforts are still in their infancy. A new challenge in the treatment of the cardiovascular disease is cellular transplantation or cellular cardiomyoplasty.