[59], Midazolam is a short-acting benzodiazepine in adults with an elimination half-life of one to four hours; however, in the elderly, as well as young children and adolescents, the elimination half-life is longer.

Synonyms (Other Words) for Well-versed & Antonyms (Opposite Meaning) for Well-versed. }); By using our services, you agree to our use of cookies. This is the British English definition of well-versed.View American English definition of well-versed. "Sedation Management in Australian and New Zealand Intensive Care Units: Doctors' and Nurses' Practices and Opinions.". name: "identityLink", bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '201356', zoneId: '990432', position:'atf' }}, gads.async = true; It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. ; Larsson, P.; Lönnqvist, PA.; Wolf, AR. [39] Additional caution is required in critically ill patients, as accumulation of midazolam and its active metabolites may occur. (2004). Symptoms of hypotonia and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth. 'max': 30, addPrebidAdUnits(pbAdUnits); A Rastegar, Darius; I Fingerhood, Michael (2005). { bidder: 'ix', params: { siteId: '347852', size: [300, 50] }}, Spina, SP. [11][29] Midazolam is effective for refractory status epilepticus, and has advantages of being water-soluble, having a rapid onset of action and not causing metabolic acidosis from the propylene glycol vehicle, which occurs with other benzodiazepines. { bidder: 'onemobile', params: { dcn: '8a9690ab01717182962182bb79c60011', pos: 'met_topslot_mobile_flex' }}, "Herb-drug interactions: a literature review". { bidder: 'onemobile', params: { dcn: '8a9690ab01717182962182bb779d000f', pos: 'met_topslot_728x90' }}, pbjs.que.push(function() { Another maker is Roxanne Laboratories; the product in an oral solution, Midazolam HCl Syrup, 2 mg/mL clear, ia a red to purplish-red syrup, cherry in flavor. {code: 'ad_topslot', pubstack: { adUnitName: 'met_topslot', adUnitPath: '/4581210/met_topslot' }, mediaTypes: { banner: { sizes: [[728, 90]] } },

[63][64] The benzodiazepine drug alprazolam was synthesised in 1976 from midazolam[65][66] and introduced to the United States market in 1981. storage: { Potokar J, Coupland N, Wilson S, Rich A, Nutt D (September 1999). Tokunaga S; Takeda Y, Shinomiya K, Hirase M, Kamei C. (February 2007). {code: 'ad_btmslot', pubstack: { adUnitName: 'met_btmslot', adUnitPath: '/4581210/met_btmslot' }, mediaTypes: { banner: { sizes: [[300, 250]] } }, Another word for versed: knowledgeable, experienced, skilled, seasoned, qualified | Collins English Thesaurus

[15][30], Dormicum brand midazolam is marketed by Roche as white, oval, 7.5 mg tablets in boxes of two or three blister strips of 10 tablets, and as blue, oval, 15 mg tablets in boxes of two (Dormonid 3x) blister strips of 10 tablets. A windows (pop-into) of information (full-content of Sensagent) triggered by double-clicking any word on your webpage. Authier, N.; Balayssac, D.; Sautereau, M.; Zangarelli, A.; Courty, P.; Somogyi, AA. iasLog("criterion : met_l = en"); . Treatment is supportive; activated charcoal can be used within an hour of the overdose. Arcangeli, A.; Antonelli, M.; Mignani, V.; Sandroni, C. (Nov 2005). name: "_pubcid",

{code: 'ad_topslot', pubstack: { adUnitName: 'met_topslot', adUnitPath: '/4581210/met_topslot' }, mediaTypes: { banner: { sizes: [[320, 50], [320, 100]] } }, "The effects of concurrent atorvastatin therapy on the pharmacokinetics of intravenous midazolam". if(success && (tcData.eventStatus === 'useractioncomplete' || tcData.eventStatus === 'tcloaded')) { dfpSlots['topslot'] = googletag.defineSlot('/4581210/met_topslot', [[728, 90]], 'ad_topslot').defineSizeMapping(mapping_topslot).setTargeting('sri', '0').setTargeting('vp', 'top').setTargeting('hp', 'center').setTargeting('ad_group', Adomik.randomAdGroup()).setTargeting('ad_h', Adomik.hour).addService(googletag.pubads()); var pbMobileLrSlots = [
(Jun 2006). { bidder: 'pubmatic', params: { publisherId: '158679', adSlot: 'met_topslot' }}]}]; type: "cookie", Mandrioli R, Mercolini L, Raggi MA (October 2008). },{ The tablets are imprinted with "Roche" on one side and the dose of the tablet on the other side. { bidder: 'ix', params: { siteId: '346531', size: [300, 250] }}, { bidder: 'ix', params: { siteId: '347868', size: [320, 50] }}, bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '201356', zoneId: '990412', position:'btf' }}, bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '201356', zoneId: '990416', position:'atf' }}, Bellù, Roberto. googletag.cmd.push(function() { (Mar 2008). pbjs.setConfig(pbjsCfg); (MeSH)A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. Contact Us }; ; Macfarlane, TC. { bidder: 'onemobile', params: { dcn: '8a9690ab01717182962182bb79c60011', pos: 'met_btmslot_mobile_flex' }}, ], antianxiety drug, anxiolytic, anxiolytic drug, minor tranquilizer, minor tranquilliser, minor tranquillizer - muscle relaxant - name[Hyper. 'min': 0, Find more ways to say versed, along with related words, antonyms and example phrases at Thesaurus.com, the world's most trusted free thesaurus. [69] In acute medicine, midazolam has become more popular than other benzodiazepines, such as lorazepam and diazepam, because it is shorter lasting, is more potent, and causes less pain at the injection site. bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '201356', zoneId: '990432', position:'atf' }},

Midazolam infusions may induce tolerance and a withdrawal syndrome in a matter of days.

This seems to be related to the altered state of consciousness or disinhibition produced by the drug. Synonyms: abreast, acquainted, au courant… Antonyms: ignorant, unacquainted, unfamiliar… userSync: {

[13][14] Midazolam is superior to diazepam in impairing memory of endoscopy procedures, but propofol has a quicker recovery time and a better memory-impairing effect. Another word for versed. {code: 'ad_rightslot', pubstack: { adUnitName: 'met_rightslot', adUnitPath: '/4581210/met_rightslot' }, mediaTypes: { banner: { sizes: [[300, 250]] } }, iasLog("exclusion label : wprod"); Letters must be adjacent and longer words score better. The toxicity of benzodiazepine overdose and risk of death is also increased in the elderly and those with obstructive pulmonary disease or when used intravenously. Brown, TB. Arayne, MS.; Sultana, N.; Bibi, Z. Midazolam is the only water-soluble benzodiazepine available. Give contextual explanation and translation from your sites ! { bidder: 'onemobile', params: { dcn: '8a9690ab01717182962182bb79c60011', pos: 'met_topslot_mobile_flex' }},

Atorvastatin administration along with midazolam results in a reduced elimination rate of midazolam. Patients with renal dysfunction may exhibit prolongation of elimination half-life for both the parent drug and its active metabolite, with accumulation of these two substances in the bloodstream and the appearance of adverse depressant effects. { bidder: 'ix', params: { siteId: '347852', size: [300, 250] }}, The wordgames anagrams, crossword, Lettris and Boggle are provided by Memodata. A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. [40] Kidney or liver impairments may slow down the elimination of midazolam leading to prolonged and enhanced effects. Reves JG, Fragen RJ, Vinik HR, Greenblatt DJ (1985). See more. var mapping_leftslot = googletag.sizeMapping().addSize([725, 0], [[160, 600]]).addSize([0, 0], []).build(); var pbTabletSlots = [ [58] Grapefruit juice reduces intestinal 3A4 and results in less metabolism and higher plasma concentrations. var pageUrlSetting = location.protocol + '//' + location.host + location.pathname; The antidote for an overdose of midazolam (or any other benzodiazepine) is flumazenil (Anexate). Gradual reduction of midazolam after regular use can minimise withdrawal and rebound effects. Cyproheptadine may be superior to nitrazepam in the treatment of insomnia, as it enhances sleep quality based on EEG studies. Find English word Versed meaning in Urdu at UrduWire online English to Urdu dictionary. Fetal risks and pharmacology]". [73], anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp, noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr, This entry is from Wikipedia, the leading user-contributed encyclopedia. { bidder: 'appnexus', params: { placementId: '13531848' }}, Dictionary.com Unabridged ○   Wildcard, crossword
; Ensom, MH. gads.src = (useSSL ? [71] In the United Kingdom, midazolam is a Class C controlled drug. Children and elderly individuals or those with a history of alcohol abuse and individuals with a history of aggressive behavior or anger are at increased risk of paradoxical effects.

{ bidder: 'onemobile', params: { dcn: '8a9690ab01717182962182bb779d000f', pos: 'met_leftslot_160x600' }}, Beran, RG. This is the British English definition of versed.View American English definition of versed.. Change your default dictionary to American English. Key:DDLIGBOFAVUZHB-UHFFFAOYSA-N Y, Midazolam[1] ( /mɪˈdæzəlæm/, marketed in English-speaking countries under the trade names Dormicum,[2] Hypnovel,[3] and Versed,[4] is a short-acting drug in the benzodiazepine class developed by Hoffmann-La Roche in the 1970s. [52] Therefore, efforts directed toward monitoring drug interactions and preventing injuries from midazolam administration are expected to have a substantial impact on the safe use of this drug. ), http://www.masc.co.za/dormicumpackage.htm, http://www.roche-australia.com/downloads/hypnovel-pi.cfm?action=get, http://www.nlm.nih.gov/medlineplus/druginfo/meds/a609014.html, "Benzodiazepine metabolism: an analytical perspective", http://www.benthamdirect.org/pages/content.php?CDM/2008/00000009/00000008/0009F.SGM, http://books.google.com/?id=-YI9P2DLe9UC&pg=PA588, http://books.google.com/?id=TI8DHMKDF-4C&pg=PA212, http://books.google.com/?id=DKUQ5YrFZd8C&pg=PA80, "Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children", http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001905/pdf_fs.html, "Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. storage: { if(window.__tcfapi) De Cosmo, G.; Congedo, E.; Clemente, A.; Aceto, P. (Nov 2005). [15] Midazolam, like many other benzodiazepines, has a rapid onset of action, high effectiveness and low toxicity level. iasLog("__tcfapi removeEventListener ", success);